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Whether this reflects direct BPC-157 effects on microglia (which do not express clearly identified BPC-157 receptors to date) or indirect effects through BBB protection and reduced peripheral immune cell infiltration is a mechanistic distinction requiring further research

Dall E, Brandstetter H

This often leads to: Increased oil production More persistent hormonal acne Skin dryness combined with breakouts Changes in skin texture Perimenopause acne is often characterized by unpredictable flare-ups, while menopause acne may become more persistent due to ongoing hormonal imbalance

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