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Bioavailability the measure of how much of a substance actually enters your bloodstreamis the biggest hurdle

Quercetin and fisetin treatment in MPTP-lesioned mice or cell cultures increases cell viability and inhibits apoptosis, accompanied by lower levels of proinflammatory cytokines like tumor necrosis factor- (TNF-) and interleukin-6 (IL-6) (22)

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Chatterjee S, Dutta M., Vitamins as nutraceuticals

[Piperaceae] (Kadukmy) in SHR showed that Kadukmy significantly reduced systolic and diastolic blood pressure, increased serum NO levels, decreased MDA levels, and reduced total cholesterol (Mohd Zainudin et al., 2015)