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Since we know very little about the biological underpinnings of aging and know even less about how to efficiently model it in the laboratory, the promotion of an anti-aging drug often conjures up more questions than it answers

[DOI] [PubMed] [Google Scholar] 98.Zinngrebe J, Rieser E, Taraborrelli L, Peltzer N, Hartwig T, Ren H, et al

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NOX is activated by CS to produce ROS in a variety of cell types, including lung epithelial cells [112,113], tracheal and arterial smooth muscle cells [114,115,116], vascular endothelial cells [109,117,118,119], cancer cells [120,121], as well as macrophages and neutrophils [122]

These studies indicate that reduction of apoCIII by antisense oligonucleotide inhibition significantly reduces circulating triglyceride levels (654,655)