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A 30 mg vial at a 2.5 mg weekly dose lasts 12 weeks, well beyond the 28-day reconstituted shelf life
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CD8 + cytotoxic T lymphocytes mediate direct thyrocyte lysis via perforin, granzymes, and proteoglycans, and are recruited and activated by autoreactive CD4 + T cells through IL-12 and IFN- signaling
