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2021;25(1):s40824-021-0022
API, active pharmaceutical ingredient
The molecular interactomes that underpin pressure-sensitive and insensitive aspects of POAG remain to be fully characterized with potential clues from recent genome-wide association study (GWAS) analyses of adult-onset POAG loci including genes that encode cholesterol-binding caveolin proteins CAV1/2, ABCA1 (ATP-binding cassette transporter 1), TGFBR3 (transforming growth factor beta receptor 3), FOXC1 (forkhead box C1), ELOVL5 (elongation of long chain fatty acids family member 5), ATOH7 (atonal homolog 7), CYP1B1 (a cytochrome P450 enzyme) and ATXN2 (ataxin isoform 2) proteins
SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system
Genetics, life circumstances, trauma history, sleep quality, hormonal status, physical health, and social support all play roles
