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Targeted validations then demonstrated that PenB is the predominant -lactamase in K56-2 and primary target of AVI

Recent work suggests an interaction with the JAK-2/STAT-3 pathway, involved in the inflammatory response and cell survival, reinforcing the hypothesis of a pleiotropic mechanism of action

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Each model answers a different experimental question, and none should be directly converted into claims about human or veterinary outcomes

Cerebral Hypoperfusion Many of the pathophysiological findings in ME/CFS are contentious because they are either not well established, poorly replicable or found only in a subset of ME/CFS patients