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Although vitamin B12 and diabetes medication arent necessarily going to interact to the point where they impact your health negatively, as we said, every case is different
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10.1126/scisignal.2001748 106 LawP
When downregulation is observed, tolerance might be measured (Gomes et al., 2002) however in some cases tolerance occurs without receptor downregulation (Polastron et al., 1994)
In addition, a lubricant can increase sensation for both partners when a condom is being used, and lube can help prevent discomfort when theres a size difference between partners
