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A person can have high total B12 but poor intracellular use, especially when MMA is high, homocysteine is high, or there are neurologic symptoms such as numbness or gait trouble

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A single temperature spike above 25C for more than two hours can denature the peptide structure irreversibly, rendering the solution inactive

The FUT2 secretor variant p.Trp154Ter influences serum vitamin B 12 concentration via holo-haptocorrin, but not holo-transcobalamin, and is associated with haptocorrin glycosylation Hum Mol Genet 2017;26:4975-88