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PGC-1 activity is modulated by post-translational modifications such as phosphorylation, acetylation, and methylation, which can either enhance or inhibit its function

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Lou D., Lou Z., Lin Y., et al

Note that this was just supplementation alone and not combined with weight lifting or exercise.[ref] In a study involving both young athletes and untrained, middle-aged adults, carnitine supplementation increased carnitine levels in the muscles.[ref] For acute aerobic performance, oral supplementation with 1-3g/day of carnitine gives a slight edge, but it doesnt affect more moderate intensity athletic performance.[ref] Supplemental L-carnitine in old age: Access this content: An active subscription is required to access this content