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Bigwigs were made using genomeCoverageBed from bedtools 2.17.0 and wigToBigWig from the UCSC toolkit after scaling per 10 million reads mapping onto exons (30, 31)

However, genetic variation is only one factor

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Montalban-Bravo G, Bose P, Alvarado Y, Daver N, Ravandi F, Borthakur G, Takahashi K, Andreeff M , Cortes JE, DiNardo CD, Jabbour E, Kadia TM, Kornblau SM, Ohanian M, Pierola AA, Huang X, Nogueras-Gonzalez GM, Bodden K, Littles K, Pierce S, Bueso-Ramos CE, Kantarjian H, Garcia-Manero G