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Unlike stimulant-based supplements where tolerance can develop, L-Carnitine works through different mechanisms that don't necessitate cycling periods

Disruption of rat testis development following combined in utero exposure to the phytoestrogen genistein and antiandrogenic plasticizer di-(2-ethylhexyl) phthalate

Distinct deficiencies arise either from genetic mutation of carnitine transporters or in association with other disorders such as liver or kidney disease

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however, an optimal dose of L-carnitine for lipid-lowering effect should be defined