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53,57,58 A meta-analysis of six randomized controlled trials with a total of 355 participants found myo-inositol was comparable to metformin with regard to its effects on fasting insulin and insulin sensitivity, testosterone, sex hormone binding globulin (SHBG), and body mass index (BMI) (a measure of body weight status) in women with PCOS, while metformin treatment carried a higher risk of adverse effects

Widespread intronic polyadenylation inactivates tumour suppressor genes in leukemia

Your gut has to be in great health to be able to take in non-liposomal B12, and even if it is it's nowhere near in the amount that you take in with a high quality B12 product like this

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Early Hum Dev 94:2530