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doi:10.1016/j.jns.2020.116715 Gasser P

The greatest IOP change induced by caffeine intake was reached after 90 min from capsule ingestion, being more accentuated for the low-caffeine consumers (+ 3.4 mmHg) than for the high-caffeine consumers (+ 1.2 mmHg)

JAMA Intern Med 175(8):1413-1415

Nat Rev Cancer 17 , 457474 (2017)

(And even if they were approved, pharmaceutical companies would shy away from them for fear of being undercut by compounding pharmacies.) If companies can sell them and make lots of money without having to prove that they do what theyre claimed to do, why wouldnt they? Zettler points out
