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Studies have shown that evodiamine (which increases acetylation levels by approximately 34-fold at a concentration of 5 M) and paclitaxel (which induces peak acetylation within 30 min at 33 nM) both enhance NLRP3 inflammasome activation and subsequent pyroptosis by specifically promoting acetylation at lysine 40 (K40) of -tubulina process dependent on the acetyltransferase MEC-17thereby revealing their mechanisms of action in cancer therapy [283, 284]

Plasma samples were used for TNF- , IL-1 , and IL-6 measurements

Sheldon RS, Grubb BP 2nd, Olshansky B, Shen WK, Calkins H, Brignole M, Raj SR, Krahn AD, Morillo CA, Stewart JM, Sutton R, Sandroni P, Friday KJ, Hachul DT, Cohen MI, Lau DH, Mayuga KA, Moak JP, Sandhu RK, Kanjwal K

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