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Description
A slight yellow-orange coloration or darkening does not indicate loss of efficacy
A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis

Proper injection technique, including rotation of injection sites and allowing the medication to reach room temperature before administration, may help minimize these local reactions

Remove air from the syringe: Remove any air bubbles by gently tapping the syringe and compressing the plunger

Persistent effects beyond two weeks suggest considering dose reduction
