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NADPH oxidases and dehydrogenases are the most prevalent enzymes in generating ROS in plant cells

This process not only destabilizes the structural integrity of the tumor, but also reprograms TAMs from the immunosuppressive M2-type to the proinflammatory M1-type

However, excessive activation of ATF4 in PD models is pathologically associated with progressive loss of dopaminergic neurons in the substantia nigra