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These findings were corroborated by in vitro experiments showing similar GLP-1 receptor signalling properties of GLP-1MK-801 and GLP-1inactive MK-801 compared with lipidated analogues of GLP-1, semaglutide and liraglutide, and the parent GLP-1 analogue (Fig

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There is also limited evidence of acute neurological and liver toxicity when evaluating different extracts, further supporting its safety, which is later demonstrated also on the clinical setting, encouraging its use for potential therapeutic applications