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For advanced cases, deep brain stimulation targeting the subthalamic nucleus effectively reduces motor fluctuations by up to 60% (3639), though it carries procedural risks including infection (35%) and cognitive adverse effects (1015%) [266, 267]

Stability of protein pharmaceuticals: an update

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[77] Non-selective alpha-blockers such as terazosin and doxazosin may also require slow dose adjustments as they can lower blood pressure and cause syncope (fainting) if the response to the medication is too strong

doi: 10.1002/clc.4960271106