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FIGURE 2 Nicotinamide adenine dinucleotide phosphate oxidase NADPH oxidase (NOX) is a primary ROS-generating enzyme that microglia express (Figure 3), but imbalance in anti- and pro-oxidant components due to injury or disease can shift hydrogen peroxide concentrations and lead to oxidative stress

This phenomenon, called aerobic glycolysis or the Warburg effect, has been exploited for visualizing tumors in the clinical setting by imaging their uptake of the radiolabeled glucose analog, [18F] fluoro-2-deoxyglucose (FDG), via Positron Emission Tomography (PET)

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the present invention further includes compositions comprising heterologous agents fused or conjugated to antibody fragments

In recent years, ample evidence has linked DED with lifestyle, highlighting the impact of exercise, diet, and sleep on its development (31)