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Based on the here-presented biochemical, structural and computational evidence, we propose that arGSTs utilize a GSH-dependent Brnsted base mechanism for conversion of the semi-stable LDOX product flavan-3,3,4-triol ( 4 ) or flavan-3-on-4-ol ( 7 ) into flav-2-en-3,4-diol ( 8 -B4), the 4-hydration species of cyanidin ( 8 ) (Extended Data Fig

15, 299305.10.1159/000111348 71 KurzG

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Phytocannabinoids, including cannabidiol (CBD) and 9 -tetrahydrocannabinol (THC), interact with the ECS, have anti-inflammatory, antioxidant, and neuroprotective properties, can ameliorate amyloid- and NFT-related pathologies, and promote neurogenesis