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Increased neuronal injury in clock gene Per-1 deficient-mice after cerebral ischemia

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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Rook JM, Hasan W, McCarson KE

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Thus, we posit that the dose of APR-246 needed to sufficiently restore wildtype function and overcome dominant negative effects of remaining p53 mutants is the major limitation in these studies

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