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Furthermore, the production of acetyl-CoA through upregulated -oxidation results in negative feedback to pyruvate and thereby glucose metabolism leading to a vicious cycle disrupting the cell metabolic homeostasis 19

This activity of carnitine can by likened to the use of sunscreen reducing downstream effects of UV (pain, redness, edema, exfoliation, melanin production, collagen damage) by physically limiting the cellular damage/stress from UV, not by the pharmacological targeting of cytokines, receptors, etc

Because it is generally accepted that acetyl-CoA derived carbon cannot end up in glucose, leucine is the only BCAA that is considered strictly ketogenic

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