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Similar content being viewed by others Introduction Fibromyalgia (FM) is a chronic condition characterized by widespread pain throughout the body, often accompanied by fatigue, sleep disturbances, cognitive impairment, and other comorbidities such as depression 1,2,3,4

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Acknowledgements The authors acknowledge Debbie Nixon, DPhil, from Costello Medical, UK for publication coordination and Noa Chapman, MSc, and Kerris Chappell-Smith, BSc, from Costello Medical, UK, for medical writing and editorial assistance based on the authors input and direction

Mitochondrial C3a receptor activation in oxidatively stressed epithelial cells reduces mitochondrial respiration and metabolism