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Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

The optimization of another HTS protocol has allowed researchers to analyze a chemical library from Maybridge HitFinder containing more than 14.000 chemically diverse compounds [332] and to report three modulators of -Syn aggregation: SynuClean-D (SC-D), ZPD-2, and ZPDm [333,334,335]

A complete understanding of the specific role of Wnt/-catenin in disease occurrence and progression can help guide the accurate use of these small-molecule drugs to maximize their efficacy and benefit more patients