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Wichman J, Winther KH, Bonnema SJ, Hegeds L

was supported by a grant from the National Research Foundation of Korea (2019R1A5A6099645)

Recent studies have reported a significant reduction in circulating ApoA-I levels in AD patients compared to cognitively healthy individuals, suggesting that ApoA-I deficiency, rather than HDL quantity alone, may contribute to increased AD risk [80]

Notably, increased circulating oxalate was recently identified as a risk factor for cardiovascular events in patients on dialysis 26,65

Research on colorectal cancer has revealed the dual regulatory role of the chromatin remodeling factor ATRX: The deletion of ATRX upregulates the function of p53 through the Daxx/MDM2 pathway (the expression of p21 is increased by 3.2 times), and at the same time inhibits the activation of the ATM/Chk2 pathway (the number of H2AX foci is reduced by 42%)