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At the genetic epidemiology level, Mendelian randomization-based analyses provide support for causal relationship hypotheses, though evidence strength remains preliminary (155)
Under oxidative stress or xenobiotic stress and increased ROS levels, Nrf2 dissociates from Keap1 and translocates to the nucleus where it binds antioxidant response elements (ARE) and activates the transcription of associated genes 50
Gabaglio M, Zamberletti E, Maneti C, Parolaro D, Rubino T
doi: 10.1186/s40001-023-01203-6, 67
