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Even if cysteine S -conjugate -lyase is responsible for the synthesis of the highly reactive and cytotoxic thiol version of cisplatin ( Figure 1 ), the activation of cisplatin into a nephrotoxin relies on the three previous steps of the classical mercapturic acid pathway involving GSTs (GSH conjugation), GT (production of CisPt-cys-glu) and dipeptidase (production of CisPt-cys
Yu H, Levesque MA, Khosravi MJ, Papanastasiou-Diamandi A, Clark GM, Diamandis EP

The images were analysed by ZEN pro software (Carle Zeiss, German), ImageJ and Photoshop CS6 (Adobe)

Additionally, the methylation status of several DMPs in the SCEZ (such as SHANK3, SBF1, and MCF2L) was validated through methylation-specific qPCR (232)

EMT is characteristic of the downregulation of E-cadherin and upregulation of N-cadherin and vimentin
