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Semaglutide requires weekly injections and often causes gastrointestinal side effects, while AOD-9604 is generally well-tolerated with minimal digestive impact

29 The junctional protein JAM-A is also involved in the barrier function, and decreased JAM-A expression has been reported in IBDs

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KW-6356 is a second-generation A2A antagonist which has shown positive results with regard to motor progression in early-stage PD, as assessed by changes in the MDS-UPDRS motor score from baseline until the end of follow-up, both in combination with levodopa (NCT03703570) and as monotherapy (NCT02939391, Table 2) (Chen et al

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