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Because it does not activate the hGH receptor (fully) and does not elevate IGF-1 in human trials, it avoids many of the growth-hormone-related side effects (such as insulin resistance) seen with full hGH therapy

Mio K, Togo-Ohno M, Tadenuma N, Ogawa R, Yamanaka C, Aoe S

Lee D-Y, Song M-Y, Kim E-H

Contact versus immersion freezing of freely suspended droplets by bacterial ice nuclei
