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The core mechanism of action of epicatechin is the inhibition of myostatin, which belongs to the transforming growth factor- (TGF-) superfamily and acts as an endogenous negative regulator of skeletal muscle mass

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Regarding its anti-inflammatory and anti-androgenic effects, vitamin D potentially diminishes advanced glycation end products (AGEs)-induced androgen synthesis via downregulating the expression of the receptor for advanced glycation end products (RAGE) and further lowers pro-inflammatory cytokine levels via inhibiting the activity of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, consequently improving glucose homeostasis (47)

Comparison of the conformation of amyloid beta (128) peptide fragment with its Lys28 N-acetyl derivative Soc Neurosci Abstr 1997

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