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Upon binding to the target molecule, the secondary or tertiary structure of the aptamer is rearranged, altering the electron transfer distance, charge distribution, and electron transfer rate between the reporter and the electrode [152]

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Specifically, glucose-lactate metabolism in tumor tissues increased significantly by tenfold compared to normal tissues under aerobic conditions, highlighting the differences between cancer cells and normal cells [2]

doi: 10.1192/bjp.2018.144 98 McEwenBSGianarosPJ

Leuk Res 32(12):1895-1902, 2008