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Its chemical properties, including susceptibility to autoxidation and its role as a co-catalyst in peroxidase-mediated reactions, may facilitate ROS production

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[114], using beta-carotene-15,15-oxygenase and beta-carotene-9,10-oxygenase double knockout mice, the oral administration of lycopene at 2.3 mg/g for 24 weeks resulted in significantly decreased severity of hepatic steatosis and triglyceride levels but significantly increased sirtuin 1 and fatty acid oxidation compared to control counterparts fed a high-fat diet

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In addition, hepatic arginine synthesis does not occur in chickens as the arginase activity is relatively higher in the liver
