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Notwithstanding these caveats, our analysis provides a valuable big-picture assessment that highlights an actionable environmental determinant of AF on a worldwide scale

Furthermore, T lymphocytes secrete EVs that, through a positive feedback mechanism, stimulate epithelial cells to release IL-6 and inhibit the secretion of the anti-inflammatory cytokine IL-10, further damaging the airways (42)

It should be noted that these are the first studies of this type, including Polish patients with prostate cancer, comparing the results with a properly selected control group

Given that growth hormone (GH) controls the level of IGF-1 in the circulation, the GH/insulin/IGF-1 pathway has been called the somatotropic axis in the regulation of mammalian longevity [2]

Cell Death Dis 13 , 132 (2022)