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Glutathione synthetase deficiency is transmitted as an autosomal recessive condition

Chronic administration of EGCg was shown to support the reduction of behavioral deficits, significantly decreasing immobility time, post-exertional fatigue, and pain sensitivity (hyperalgesia)

Most of these cases were attributable to having obesity in midlife, not exercising, and low education

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Studies have postulated that the cause may be ascribed to the reduction in the excitability of pain transmitting dorsal horn neurons via hyperpolarization due to MT1/2-melatonin binding 89