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Shaking can cause foaming, which indicates that the peptide chains are breaking and the compound is losing its efficacy for your metabolic assays

This concern is particularly relevant with aggressive caloric deficits, and cagrilintide's appetite-suppressing effects can create substantial caloric deficits

10.1016/j.neuint.2012.04.008 Neurochem

[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Ang QY, Alexander M, Newman JC, et al

Primary Degradation Pathways in Solution Understanding the chemistry of peptide degradation in solution helps explain why specific storage conditions are required: 1
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