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11C-E) [86]

Hence, requirements of specific necrosome components may be variable depending on the pathophysiology, with Toll-like receptor 3-mediated necrosis proceeding independent of RIP1 [131] and MLKL-mediated regulated necrosis proceeding independently of RIPK3 in inflammation after Con A-induced hepatitis [132]

1a, mice displaying behavioral signs of tinnitus 24 h after noise exposure were assigned to the tinnitus group (Supplementary Fig