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Since inflammation of the large intestine affects brain function through braingut interaction, patients with colitis are at a high risk of developing psychiatric disorders, such as depression and anxiety, during the exacerbation period 43,44

38,5658 However, instead of enhancing the injury mechanism as intended, this modulation changed the injury process altogether from a protein adduct-driven signaling process to one dominated by LPO

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Transthyretin Is Involved in DepressionLike Behaviour and Exploratory Activity. Journal of Neurochemistry 88: 10521058

showed that topical glutathionecyclodextrin (GSH-CD) increased intracellular GSH in mononuclear and red blood cells, decreased malondialdehyde (MDA), and significantly upregulated immune cytokines including IL-2, IFN-, IL-12p70, and TNF-