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In mice, -Klotho is primarily expressed across metabolic tissues including liver, pancreas, and adipose tissue (96, 97)
This inhibition of the acute inflammatory reaction and cytokine production by ASCs contributes to a decrease in subsequent chronic inflammation and fibrosis
Recent studies have shown that three transporter families present in mammal cells participate in glutathione transport and movement, and are called: (i) Multidrug Resistance-associated Protein (MRP) Family, (ii) cystic fibrosis transmembrane conductance regulator (CFTR) family, and (iii) organic anion-transporting polypeptide (OATP) family [97,109]
doi: 10.3389/fmicb.2016.02170
Morin hydrate mitigates cisplatin-induced renal and hepatic injury by impeding oxidative/nitrosative stress and inflammation in mice
