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doi: 10.1046/j.1471-4159.1994.63010108.x

Selenium deficiency also results in congestive cardiomyopathy, heart failure, cardiomegaly, increased risk of cancer, infection, inflammatory disease, diabetes, retarded wound healing, and infertility, while excess selenium results in brittle hair and brittle, thickened, stratified nails or loss of both hair and nails (Hariharan and Dharmaraj 2020

doi: 10.1088/0957-4484/25/48/485102

doi: 10.1016/0968-0004(90)90206-q

Lee et al.'s simpler topical approach produced more modest but still significant results suggesting a spectrum from basic topical use to advanced clinical delivery