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Stoichiometry of the TCA Cycle The overall stoichiometry of the TCA cycle is: acetyl-CoA + 3NAD + + FAD + GDP + P i + 2H 2 O 2CO 2 + 3NADH + FADH 2 + GTP + 2H + + CoASH Role of Lactate as Driver for TCA Cycle Activity The lactate produced by anaerobic glycolysis does not simple serve as an intracellular carbon source for hepatic glucose production via gluconeogenesis

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5 Anti-ASCVD effect of GA Atherosclerosis contributes to ASCVD by narrowing arteries or forming thrombi, thereby obstructing blood flow to the heart (coronary artery disease), brain (ischemic stroke), or lower limbs (peripheral vascular disease)

Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord