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doi: 10.1038/s41591-018-0128-1
Nature 367 (6464), 607614

In treated subjects, the mean estimated ALSFRS-R total score was 42.2 at baseline, 26.9 at month 12 and 11.5 at month 24, with a mean slope of 1.3, as compared to 43.4, 27.7 and 12.1, with a mean slope of 1.3 in not treated subjects (slope difference: 0.0
