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Epidemiology and global burden of Parkinsons disease Parkinsons disease (PD) is one of the fastest-growing neurological disorders globally, driven primarily by population aging, environmental exposures, and improved longevity

Here we describe a class of synthetic antibiotics inspired by scaffolds derived from natural products

In a number of experimental and clinical studies, Lipoic acid has now been shown to be useful in the treatment of such conditions as diabetes, ischemia-reperfusion damage, neurodegeneration, heavy-metal poisoning, radiation damage and HIV infection and may offer significant protection against stroke, heart disease and cataracts (Packer L et al., 1995)

An alternative approach escalates both agents simultaneously but at slower intervals, extending the total escalation period to twenty weeks or longer

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