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Despite widespread adoption, these agents are not approved by the U.S

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If you are pregnant, nursing, or have a medical condition, consult your healthcare provider before use

Methods A comprehensive search was performed on various databases including PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov from inception up to April 29, 2024, to identify randomized controlled trials (RCTs) that assessed the efficacy of once-weekly tirzepatide compared to a placebo in adults with or without T2D