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Uncoupling activity and metabolic stability of 2,6-dinitro-4-(octyloxy)phenol We were interested to explore whether the instability of the octoxy ether bond is specific to NMY1009

DDR, DNA Damage Response

The velocity was calculated by multiplying the fitted rate constant by the fitted reaction amplitude

As the first Rbs, we focused on berberine 13,14 because it selectively binds to G-quadruplex (G4) structures formed from guanine-rich sequences, which play an important role in gene expression regulation and are promising drug targets 15,16,17,18

Poole D, Rossi C, Anghileri A, Giardino M, Latronico N, Radrizzani D et al