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By integrating patient-specific physiological data with mechanistic PK/PD models, digital twins enable real-time prediction of nanoparticle circulation, tissue accumulation, and clearance

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Mithaiwala MN, Santana-Coelho D, Porter GA, Oconnor JC (2021) Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications

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