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[DOI] [PubMed] [Google Scholar] 22.Sekhar R.V., McKay S.V., Patel S.G., Guthikonda A.P., Reddy V.T., Balasubramanyam A., Jahoor F

In a pivotal randomized, double-blind, placebo-controlled vitamin D and omega 3 trial (VITAL) trial with a two-by-two factorial design (n=25 871 participants followed for a median of 5.3 years), vitamin D (2000IU/day) supplementation for five years [with or without omega 3 fatty acid (1000 mg/day)] had a significant reduction in the risk of confirmed autoimmune disease of 22% (HR 0.78 [95% CI: 0.61, 0.99], p=0.05) (180)

Subjects were initially treated for 6 months of on-demand therapy and then randomized to 12 months of either a standard prophylaxis regimen (20 to 40 IU/kg every 48 hours) or PK-driven prophylaxis regimen (20 to 80 IU/kg every 72 hours)