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This epigenetic silencing effectively inhibits class-switch DNA recombination (CSR), somatic hypermutation (SHM), and plasma cell differentiation, thereby reducing the production of both T-dependent and T-independent autoantibodies (e.g., anti-dsDNA antibodies)

Polymorphisms in interferon regulatory factor 7 reduce interferon- responses of plasmacytoid dendritic cells to HIV-1

[1] Galzigna L et al

A secondary effect of this stress is activation of Nrf2 and its target genes resulting in compensatory higher GSH levels and induction of antioxidant genes in the livers of these mice, which makes these livers more resistant to additional acute stress such as APAP toxicity [151]

In the early phase of MRD following chemotherapy in AML patients, cachexia-like metabolic reprogramming may support the energy demands for leukemia regeneration and relapse