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[DOI] [PMC free article] [PubMed] [Google Scholar] 243.Pan X., Tsimbas K., Kurzman I.D., Vail D.M
Active Metabolites: Does first-pass metabolism generate active metabolites contributing to biological effects

A synthetic analog of the endogenous 43 amino-acid peptide of the same name, TB4 stimulates tissue growth and repair while improving immune and inflammatory responses

The bidirectional communication between the gut microbiota and the host involves complex neural, endocrine, and immune pathways, each playing distinct roles in modulating metabolic and cognitive functions: 2.1.4 Neural pathways The gut-brain axis facilitates communication between the gut microbiota and the central nervous system (CNS) through the vagus nerve (Carabotti et al., 2015)

Silvestroff L, Bartucci S, Soto E, Gallo V, Pasquini J, Franco P
