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Heavy doses over a long time are linked to a higher likelihood of heart disease and stroke

Hydrocortisone reinforces the bloodbrain barrier properties in a serum free cell culture system

This tends to become apparent within 1-2 weeks , as patients feel less fatigued and experience greater physical endurance

Cardiovasc Res
PET studies suggest that approximately 7080% MAO-A occupancy may be sufficient for antidepressant effects (Sacher et al., 2011)
