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Risks of Concomitant Use or Discontinuation of Cytochrome P450 3A4 Inhibitors and Inducers Concomitant use of Oxycodone and Acetaminophen Tablets with a CYP3A4 inhibitor, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritonavir), may increase plasma concentrations of oxycodone hydrochloride and prolong opioid adverse reactions, which may cause potentially fatal respiratory depression [see Warnings], particularly when an inhibitor is added after a stable dose of oxycodone and acetaminophen tablets is achieved
I was approved within hours
Phase I awards typically range from $150,000 to $250,000 and cover a period of six months to a year
Misuse, not in accordance with the intended use, is the sole responsibility of the purchaser
Like all meta-analyses, our analyses of covariates were limited by the information provided in the papers we reviewed
